IOTA – is a multidisciplinary group founded by Dirk Timmerman, Lil Valentin, Tom Bourne, William Collins, Herman Verrelst, Sabine Van Huffel, and Ignace Vergote in 1999 to develop standard terms, definition, and simple descriptors to describe sonographic features of adnexal masses. Why choose International Ovarian Tumor Analysis Algorithms-simple rules? These led to the formation of different types of the scoring system for categorizing adnexal masses into benign and malignant namely, risk of malignancy index (RMI), Risk of Ovarian Malignancy Algorithm (ROMA), International Ovarian Tumor Analysis (IOTA)-simple rules, IOTA-AdneXa model, Sassone morphology index, etc., RMI, ROMA use CA 125 values along with USG findings and menopausal state, calculation often being complex. To overcome these drawbacks, various classification systems have been designed, taking USG findings and combining them with other modalities to differentiate adnexal masses. Moreover, clear guidelines on terminology and classification for the USG-based description of the adnexal masses were lacking. Ultrasonography (USG)-based subjective pattern recognition assessment depends on the operator's experience, hence is operator dependent. CT scan and MRI are done later to see nodal involvement, disease extent in the upper abdomen, the architecture of the masses, and if doubt arises for the origin of mass, for example, gastro-intestinal tract, urinary or retro-peritoneum. It is the most common and widely tool used in diagnosing pelvic and abdominal pathology. Ultrasound be it trans-vaginal or trans-abdominal sonography is the first-line preoperative investigation for ovarian masses. Imaging techniques such as ultrasound, computerized tomography (CT) scan, magnetic resonance imaging (MRI) are used to see the soft-tissue architecture, growth, and lymph nodes. CA-125 is the most common tumor marker in all the cases, but it has also shown to have false-positive results as may be raised in many nonmalignant pathologies too. In younger patients generally, germ cell markers are used, while for middle age and older women, epithelial markers are preferred. The commonly available tests are tumor markers or radiological imaging.įew of the tumor markers include-alpha-fetoprotein, beta-human chorionic gonadotrophin, CA 19-9, CA 125, carcinoembryonic antigen, human epididymis 4 (HE-4), lactate dehydrogenase, inhibin A and B and many more. Various diagnostic tests available to date are not very dependable, and the need for a reliable method cannot be ignored. Preoperative diagnosis of adnexal mass as benign or malignant can change the approach to treatment, nonetheless is found to be most challenging. Timely diagnosis of the nature of the mass ensures appropriate referral to gyne-oncologist and treatment. Why is it important to diagnose ovarian malignancies early? The answer to this lies in the fact that the majority of ovarian malignancies are epithelial ovarian cancers (EOC), which are rapidly progressing tumors. Infertility, early menarche and late menopause, exogenous hormonal use, high body mass index (BMI), and genetic mutations are considered some of the risk factors for ovarian cancers. This high mortality is due to late diagnosis in an advanced stage where mortality is high. I honestly can’t picture IOTA not being on that list of winners (only a major flaw in the code can bring it down, which we all know is very possible and part of the risk of investing) and could even see it in the top 3 in a few years.According to Globocan 2018, Ovarian cancers are the 7 th common cancers in females worldwide but have the highest mortality rates among all gynecological cancers. I see about 15 major winners in the crypto space and I research and read about them all day. Bringing in the right people and making partnerships in the background. Unlike other teams these guys are building from the inside out. I’m a conservative thinker so even with all this good happening I still see it at no higher than 6 billion in market cap, which is honestly on the extremely optimistic side, and would put 1 Miota at about $2.20 (I consider this best case scenario). The question is will there be any major catalyst for a price jump? Will they announce any partnerships? Will it come to multiple exchanges? Will the tip bot be pushed out to social media sites and will other sites integrate a plugin for donations (word press is already doing this)? If that happens then I can see it exploding. I can easily picture it doubling by next year without any major announcements so 3 billion by the end of 2018 is possible imo. I believe IOTAs trajectory will continue up just off word of mouth alone. Anyway, I’ve never predicted prices before but why not give it a shot. I’m pretty new to posting on reddit so who knows.
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